Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 8, Pages 1963-1968Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.01.010
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A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06-91.35 muM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.
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