Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 8, Pages 1859-1866Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.01.039
Keywords
prodrug activation; selective chemotherapy; enzymes; ADEPT
Ask authors/readers for more resources
Two new prodrugs of CPT were synthesized, based on carbamate linkages between the 20-hydroxy group of CPT and a linker designed to be enzymatically removed by either Penicillin-G-Amidase or catalytic antibody 38C2. Cell growth inhibition assays showed an up-to-2250-fold difference in toxicity between the prodrugs and the active drug. A significant increase in toxicity was observed upon incubation of the enzyme or the catalytic antibody with the corresponding prodrug The described derivatives of CPT further our knowledge in the design of prodrugs for use in selective approaches for targeted chemotherapy. (C) 2004 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available