Journal
NEUROSCIENCE LETTERS
Volume 359, Issue 3, Pages 159-162Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.02.029
Keywords
akt; transgenic mouse; damage-induced neuronal endopeptidase; Endothelin Converting Enzyme Like (ECEL); ischemia; neuronal protection
Categories
Ask authors/readers for more resources
Transgenic mouse lines expressing the active form Akt gene under the control of the damage-induced neuronal endopeptidase (DINE) promoter were made from three different founder mice, and its neuroprotective potential against ischemic brain damage was investigated. Twenty-four hours after middle cerebral artery occlusion, two DINE-Akt-transgenic mouse lines displayed reductions of the infarcted area by 35% compared to the wild-type littermate. RT-PCR assays showed a high level of transgene in response to ischemic brain damage in these lines. These results suggest that the DINE promoter is a useful promoter, which responds to neuronal insults and that the Akt-induced neuroprotective effect against ischemic damage is potent in vivo. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available