Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 189, Issue 8, Pages 1540-1544Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/382486
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Pneumocystis causes pneumonia in immunodeficient hosts but also likely causes infection in healthy hosts. To characterize infection in healthy mice, we developed and validated a real-time polymerase chain reaction assay for quantitation of Pneumocystis carinii f. sp. muris. In healthy mice exposed to Pneumocystis-infected animals, organisms were first detected at 2 - 3 weeks, peaked at 5 - 6 weeks, and were cleared by 7 - 9 weeks. The peak organism load in healthy animals was 2 - 3 logs lower than that in immunodeficient animals. This approach should facilitate studies of anti-Pneumocystis immune mechanisms in healthy hosts and provide insights into the development of Pneumocystis pneumonia in immunodeficient hosts.
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