Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 35, Issue 2, Pages 379-387Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0731-7085(03)00647-2
Keywords
hesperetin; naringenin; beta-cyclodextrin; phase solubility studies; dissolution
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The inclusion into the beta-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of beta-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined. (C) 2003 Elsevier B.V. All rights reserved.
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