Journal
TETRAHEDRON LETTERS
Volume 45, Issue 17, Pages 3359-3362Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.03.020
Keywords
combretastatin; 1,3-dipolar cycloaddition; nitrile oxide
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A series of compounds related to combretastatin A-4, containing a five-membered heterocyclic ring interposed between the two phenyl groups have been Prepared. Synthetic approach involves 1,3-dipolar cycloaddition of various 3,4,5-trimethoxyphenyl units with an in situ generated nitrile oxide from a suitable aldoxime using sodium hypochlorite. Depending oil the nature of the dipolarophile, 3,5-diarylisoxazole derivatives obtained along with the 3,4-regioisomeric isomers. (C) 2004 Elsevier Ltd. All rights reserved.
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