Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 16, Pages 5727-5731Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0308178101
Keywords
-
Categories
Ask authors/readers for more resources
The amplifying asymmetric autocatalysis discovered by Soai and coworkers in 1995 does not fit easily into the extensively investigated framework of organozinc alkylation of aldehydes. In that case the catalyst is a monomeric Zn chelate that functions as both Lewis acid and Lewis base, permitting the simultaneous coordination of both dialkylzinc reagent and aldehyde reactant. By contrast, the Soai reactants are rigid gamma-aminoaldehydes that cannot function as mononuclear chelates. Structural and computational evidence for a binuclear resting state is presented, and the energetics of mono-, di-, tri-, and tetrameric species accessible to the reacting system have been computed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available