Journal
NEUROSCIENCE LETTERS
Volume 360, Issue 1-2, Pages 9-12Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.01.001
Keywords
urinary tract physiology; afferent nerve; electrical stimulation; urinary catheterization; sacral reflex; pudendal reflex; spinal cord injury; human subject
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Funding
- NCRR NIH HHS [M01RR00080] Funding Source: Medline
- NICHD NIH HHS [K25 HD40298] Funding Source: Medline
- NINDS NIH HHS [R21NS43450] Funding Source: Medline
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An excitatory reflex between urethral flow receptors and the bladder has been established in animals, but attempts to demonstrate this reflex in humans using urethral fluid flow have been inconclusive. Intraurethral electrical stimulation has recently been shown to generate bladder contractions in animals and was applied to study the presence of an excitatory urethra to bladder reflex in humans. The prostatic urethra was stimulated electrically via a catheter-based electrode in five men with complete spinal cord injury. Bladder contractions were Generated in four of five individuals. however, only when the bladder volume was sufficiently large. These results demonstrate the presence of a volume dependent excitatory bladder reflex mediated by urethral afferent nerve fibers and the lumbosacral spinal cord. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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