Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 56, Issue 7, Pages 1023-1050Publisher
ELSEVIER
DOI: 10.1016/j.addr.2003.10.040
Keywords
drug delivery; drug release; drug targeting; drug carriers; polymer prodrugs; pH-sensitivity; acid-sensitive; cancer
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Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for therapeutic activity of most macromolecular anti-cancer conjugates. Incorporation of acid-sensitive spacers between the drug and carrier enables release of an active drug from the carrier in a tumor tissue. either in slightly acidic extracellular fluids or, after endocytosis, in endosomes or lysosomes of cancer cells. This paper reviews advances in development and study of properties of various acid-sensitive macro molecular drug delivery systems, starting from simple polymer-drug conjugates to ending with site-specific antibody-targeted polymer-drug conjugates. (C) 2004 Elsevier B.V. All rights reserved.
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