Journal
FEBS LETTERS
Volume 564, Issue 1-2, Pages 4-8Publisher
WILEY
DOI: 10.1016/S0014-5793(04)00258-3
Keywords
heterochromatin; nucleosome; histone; higher order folding; chromatin 3D structure
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Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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