Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 491, Issue 1, Pages 37-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2004.02.058
Keywords
vagus; prostanoid; prostaglandin; DP receptor; 5-HT3 receptor; depolarization; neurone; nervous; (ferret)
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We have investigated the actions of various prostanoid receptor agonists on an isolated preparation of the ferret cervical vagus using a grease-gap extracellular recording technique. The potency ranking for depolarization was BW245C (5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin; DP-selective, EC50=0.14 muM)>prostaglandin E-2 (nonselective EP agonist)>U-46619 (11alpha, 9alpha-epoxymethano-15S-hydroxyprosta-5Z, 13E-dienoic acid; TP agonist)>prostaglandin F(2)alpha (FP receptor agonist). Sulprostone (EP1/EP3-selective), fluprostenol (FP-selective) and cicaprost and iloprost (both IP-selective) had minimal effects. It is likely that DP2, EP2/EP4 and TP receptors are present on the vagal fibres of the ferret. (C) 2004 Elsevier B.V. All rights reserved.
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