Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 17, Pages 6421-6426Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0308014101
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Funding
- NHLBI NIH HHS [N01-HV-28186, N01HV28186] Funding Source: Medline
- NIGMS NIH HHS [GM 559343, R01 GM068819, GM 068819] Funding Source: Medline
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The expression of certain genes involved in fundamental metabolism is regulated by metabolite-binding riboswitch elements embedded within their corresponding mRNAs. We have identified at least six additional elements within the Bacillus subtilis genome that exhibit characteristics of riboswitch function (glmS, gcvT, ydaO/yuaA, ykkC/yxkD, ykoK, and yybP/ykoY). These motifs exhibit extensive sequence and secondary-structure conservation among many bacterial species and occur upstream of related genes. The element located upstream of the glmS gene in Gram-positive organisms functions as a metabolite-dependent ribozyme that responds to glucosamine-6-phosphate. Other motifs form complex folded structures when transcribed as RNA molecules and carry intrinsic terminator structures. These findings indicate that riboswitches serve as a major genetic regulatory mechanism for the control of metabolic genes in many microbial species.
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