Journal
ORGANIC LETTERS
Volume 6, Issue 9, Pages 1377-1380Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049835v
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Funding
- NIAID NIH HHS [AI44954, AI34501] Funding Source: Medline
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Efficient syntheses of guanidine-bridged poly(ethylene glycol) linkers of various lengths in fully protected form are reported for both solution- and solid-phase protocols. The application of such linkers in the construction of water-soluble and high-affinity multivalent ligands against cholera toxin is demonstrated. Synthetic intermediates for multivalent ligands as large as 20 kDa in molecular weight have been assembled using presynthesized linkers. The final ligands are highly water-soluble, thus enabling proper biophysical characterization.
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