Journal
ORGANIC LETTERS
Volume 6, Issue 9, Pages 1453-1456Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049682b
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A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and aldehydes in the presence of NH4OAc is described. Under microwave irradiation, alkyl-, aryl-, and heteroaryl-substituted imidazoles are formed in yields ranging from 80 to 99%. Short syntheses of lepidiline B and trifenagrel illustrate the utility of this approach.
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