Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 56, Issue 8, Pages 1099-1109Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2004.01.010
Keywords
folate receptor recycling; folate receptors in lipid rafts; sorting of receptors in endosomes; GEECs; glycosylphosphatidylinositol anchored proteins
Categories
Ask authors/readers for more resources
Folate absorption is primarily mediated by a membrane transporter with micro-molar affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations in extracellular milieus; membrane folate receptors (FRs) with nanomolar affinities for folates are likely to substantially modulate folate availability for these transporters. Functional isoforms of FRs are anchored to the membrane by a glycolipid anchor, the glycosylphosphatidylinositol (GPI) anchor. In this chapter we discuss recent insights that have been obtained with regards to GPI-anchored protein trafficking in the context of folate transport via the GPI-anchored FR. Specifically, we focus on recent advances in elucidating the pathways and mechanisms of endocytic sorting of the GPI-anchored FR, and the connection with membrane rafts. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available