Journal
ANNALS OF HEMATOLOGY
Volume 83, Issue 5, Pages 319-321Publisher
SPRINGER
DOI: 10.1007/s00277-003-0805-z
Keywords
B-cell prolymphocytic leukemia; monoclonal anti-CD-20 antibody
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We report a patient with B-cell prolymphocytic leukemia (PLL) who was treated successfully with the monoclonal anti-CD20 antibody (rituximab). The patient had recurrent infections due to relative neutropenia, secondary to bone marrow infiltration. After treatment with monoclonal anti-CD20 antibodies (rituximab) 375 m(2)/m(2) weekly for 4 weeks, complete remission was obtained. It was documented by normalization of peripheral blood counts, disappearance of organomegaly, and by molecular cytogenetics-fluorescent in situ hybridization (FISH) on bone marrow cells. She remains in complete remission 8 months following the discontinuation of treatment. This is the second reported case of successful treatment of B-cell PLL with rituximab.
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