Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 5, Pages 841-852Publisher
WILEY
DOI: 10.1359/JBMR.040118
Keywords
stem cells; osteoblasts; adipocytes; differentiation; preadipocyte factor-1; fetal antigen 1
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Dlk-1/Pref-1 was identified as a novel regulator of human skeletal stem cell differentiation. Dlk1/Pref-1 is expressed in bone and cultured osteoblasts, and its constitutive overexpression led to inhibition of osteoblast and adipocyte differentiation of human marrow stromal cells.
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