Journal
NEUROIMAGE
Volume 22, Issue 1, Pages 367-371Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.01.022
Keywords
region of interest; spatial normalization; Talairach; coordinate transformation; affine transformation
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Disagreement between the Talairach atlas and the stereotaxic space commonly used in software like SPM is a widely recognized problem. Others have proposed affine transformations to improve agreement in surface areas such as Brodmann's areas. This article proposes a similar transformation with the goal of improving agreement specifically in the deep brain region. The task is accomplished by finding an affine transformation that minimizes the mean distance between the surface coordinates of the lateral ventricles in the Talairach atlas and the MNI templates. The result is a transformation that improves deep brain agreement over both the untransformed Talairach coordinates and the surface-oriented transformation. While the transformation improves deep brain agreement, surface agreement is generally made worse. For areas near the lateral ventricle, the transformation presented herein is valuable for applications such as region of interest (ROI) modeling. (C) 2004 Elsevier Inc. All rights reserved.
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