Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 34, Issue 5, Pages 1389-1394Publisher
WILEY
DOI: 10.1002/eji.200424858
Keywords
immune regulation; virus; CD8(+) T cells; perforin; IFN-gamma
Categories
Ask authors/readers for more resources
Using gene-targeted mice we have investigated whether perforin and/or interferon-gamma exert a direct regulatory effect on the expansion and contraction of antigen-specific CD8(+) T cells following infection with a virus (vesicular stomatitis virus) which is not controlled through these molecular effector systems. Unlike what has been observed when these molecules are essential for pathogen clearance, neither molecule was found to play an important role in regulating the kinetics of the virus-specific CD8(+) T cell response in the absence of antiviral effector activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available