Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 5, Pages 853-861Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.040120
Keywords
osteoprogenitor cells; osteoblast; adipocyte; soy phytoestrogens; genistein
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The soy phytoestrogen daidzein has biphasic dose responses, but the underlying mechanisms are not yet clear. Transcriptional and biochemical data show that PPARs, in addition to ERs, are molecular targets of daidzein, which divergently regulates osteogenesis and adipogenesis. Dose responses are the result of a balance among PPARs and between ERs and PPARs.
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