Journal
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 18, Issue 5, Pages 321-326Publisher
HINDAWI LTD
DOI: 10.1155/2004/504591
Keywords
autoimmune hepatitis; Mycophenolic acid; steroid sparing; therapy
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There are limited therapeutic options available for patients with autoimmune hepatitis in whom conventional treatment fails. A case series of five patients Unresponsive to or unable to take azathioprine, 6-mercaptopurine or corticosteroids who wore treated with mycophenolate mofetil (MMF) is reported. While on MMF, alanine aminotransferase normalized or remained normal in all patients. MMF had a steroid-sparing effect and histological remission was demonstrated in one patient after seven months of MMF. One patient experienced an uncomplicated episode of pyelonephritis. In conclusion, MMF call effectively induce and maintain remission in refractory autoimmune hepatitis patients.
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