Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 12, Issue 5, Pages 383-388Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2004.01.007
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Funding
- NIAMS NIH HHS [R01 AR 45644] Funding Source: Medline
- NIA NIH HHS [R29 AG 15108] Funding Source: Medline
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Objective: To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis Methods: Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig knees were subjected to osmotic loading. Site-matched swelling strains and fixed charge density values were used in a triphasic theoretical model for cartilage swelling to determine the modulus of the cartilage solid matrix. The degree of cartilage degeneration was assessed in adjacent tissue sections using a semi-quantitative histological grading scheme. Results: Decreased values for both moduli and surface zone fixed charge density were associated with increasing grades of cartilage degeneration. Decreases in moduli reflect damage to the collagen matrix, which give rise to greater swelling strains. Conclusion: Histological evidence of cartilage degeneration was associated with impaired cartilage mechanics in the aging Hartley guinea pig. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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