Journal
ORAL ONCOLOGY
Volume 40, Issue 5, Pages 483-489Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2003.10.002
Keywords
salivary gland neoplasms; adenoid cystic carcinoma; extracellular matrix; laminin; matrix metalloproteinases
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In a previous paper, we demonstrated that laminin-1 and its derived peptide SIKVAV modulates the morphology of an adenoid cystic carcinoma cell line (CAC2 cells). Light microscopy of CAC2 cells grown in three-dimensional preparations of SIKVAV-enriched laminin-1 showed the presence of pseudocystic spaces. Pseudocysts are hallmarks of adenoid cystic carcinoma in vivo. We hypothesized that these pseudocystic spaces could be due to the protease-inducing/ activating rote of SIKVAV. Thus, we studied the presence of matrix metalloproteinases (MMPs) in CAC2 cells treated either by laminin-1 or by SIKVAV-enriched laminin-1. Immunohistochemistry and zymography suggested that SIKVAV enhanced the secretion of MMP-2 and MMP-9 in CAC2 cells. We propose that SIKVAV induces pseudocystic formation probably through the secretion of MMPs 2 and 9. (C) 2003 Elsevier Ltd. All rights reserved.
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