Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 9, Issue -, Pages 1889-1898Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1388
Keywords
pancreatic cancer; cell signaling; growth factors; growth factor receptors; TGF beta; review
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Funding
- NCI NIH HHS [CA96122] Funding Source: Medline
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Pancreatic ductal adenocarcinomas continue to have the worst prognosis of any adult malignancy with a five-year survival rate of less than 4%. One approach to improve patient survival from pancreatic cancer is to identify new biological targets that contribute to the aggressive pathogenecity of this disease and to develop reagents that will interfere with the function of these targets. Apart from the identification of the genetic profile of pancreatic cancer, a number of studies have focused on aberrant cell signaling pathways and their role in pancreatic cancer biology and response to therapy. This review, although not comprehensive, will discuss the salient features of several of these pathways. These include the roles of TGFbeta signaling in both tumor suppression and tumor promotion and the effects of deregulation of phosphotyrosine kinase receptor signaling pathways in pancreatic cancer.
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