Journal
NATURE REVIEWS IMMUNOLOGY
Volume 4, Issue 5, Pages 387-395Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1355
Keywords
-
Categories
Ask authors/readers for more resources
T cells constitute a heterogeneous, hierarchically organized population, comprising several maturation/differentiation states that have different capacities for clonal expansion and self-renewal. Here, we argue that the relative probabilities of proliferation, differentiation and death - the cellular events that determine the population's structure, as well as its size - are not entirely preprogrammed or fixed; instead, these events are regulated dynamically through the recurrent interaction of lymphocytes with exogenous and endogenous antigens, antigen-presenting cells and each other.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available