Journal
INFECTION AND IMMUNITY
Volume 72, Issue 5, Pages 3066-3068Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.5.3066-3068.2004
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The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.
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