Journal
SCHIZOPHRENIA RESEARCH
Volume 68, Issue 1, Pages 49-63Publisher
ELSEVIER
DOI: 10.1016/S0920-9964(03)00213-5
Keywords
schizophrenia; neurodevelopment; neuropsychology; longitudinal
Categories
Funding
- NIMH NIH HHS [MH45156, MH62134, MH01433] Funding Source: Medline
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The early course of neuropsychological dysfunction in schizophrenia and the impact of treatment on these deficits need to be better specified. A sample of 45 patients with schizophrenia underwent five neuropsychological evaluations from prior to treatment with antipsychotic treatment through a 2-year follow-up period. A comparison sample of 33 matched healthy individuals underwent neuropsycliological evaluations at similar time points. At baseline, a generalized deficit across cognitive domains was evident for the schizophrenia sample. After 6 weeks of treatment, patients showed modest improvements in visual memory and visual perception, but a decline in verbal memory. Verbal memory performance returned to baseline levels by the 6-month follow-up while deficits in other neuropsychological domains persisted throughout the 2-year period. Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia. (C) 2003 Elsevier B.V. All rights reserved.
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