Journal
PROCEEDINGS OF THE NUTRITION SOCIETY
Volume 63, Issue 2, Pages 331-335Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1079/PNS2004357
Keywords
growth; hypertrophy; stretch
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Funding
- NIAMS NIH HHS [AR-45617] Funding Source: Medline
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Repeated bouts of resistance exercise produce an increase in skeletal muscle mass. The accumulation of protein associated with the growth process results from a net increase in protein synthesis relative to breakdown. While the effect of resistance exercise on muscle mass has long been recognized, the mechanisms underlying the link between high-resistance contractions and the regulation of protein synthesis and breakdown are, to date, poorly understood. In the present paper skeletal muscle will be viewed as a mechanosensitive cell type and the possible mechanisms through which mechanically-induced signalling events lead to changes in rates of protein synthesis will be examined.
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