Journal
HEARING RESEARCH
Volume 191, Issue 1-2, Pages 119-124Publisher
ELSEVIER
DOI: 10.1016/j.heares.2003.12.019
Keywords
myelin deficient; auditory brainstem responses; distortion product of otoacoustic emission; ultrastructure; cochlea; CNS-PNS junction
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In this study, we examined the auditory brainstem responses (ABRs), distortion product of otoacoustic emissions (DPOAEs) and cochlear morphology of the myelin deficient (md) rat, which completely lacks central myelin but not peripheral myelin. ABRs showed a marked prolongation not only wave II-IV latencies but also wave I latency. Cochlear nerve fibers near the modiolus lost their myelin halfway into the internal auditory canal. DPOAEs also decreased at a lower frequency of the combined tone. Since nerve fibers ending at the apical turn of the cochlea passed through central portion of the cochlear nerve, wave I prolongation of ABRs and decrease of DPOAEs at a lower frequency might originate mainly from the demyelinated CNS part of the cochlear nerve and efferent olivocochlear bundle in the internal auditory canal. (C) 2004 Elsevier B.V. All rights reserved.
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