Journal
FEBS LETTERS
Volume 565, Issue 1-3, Pages 143-147Publisher
WILEY
DOI: 10.1016/j.febslet.2004.03.090
Keywords
klotho protein; humoral factor; N-glycosylation; post-translational cleavage
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Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative Immoral factor(s) has been presumed. Newly established antibodies against Klotho allowed the detection of secreted Klotho, a candidate for the putative Immoral factor, in sera and cerebrospinal fluid. Surprisingly the secreted Klotho was 130 kDa, in contrast to the 70 kDa predicted form from klotho gene transcripts. The secreted as well as the membrane-bound Klotho proteins were suggested to form oligomerized complex. These results delineate post-translation processing of Klotho and possible regulatory. mechanisms for secretion of Klotho in vivo. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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