Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 150, Issue 1-2, Pages 163-177Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.01.017
Keywords
multiple sclerosis; DNA microarrays; gene expression; experimental autoimmune encephalomyelitis; autoimmunity
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Funding
- NINDS NIH HHS [R21 NS41623] Funding Source: Medline
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We performed microarray analysis of peripheral blood mononuclear cells (PBMCs) from multiple sclerosis (MS) patients and detected a profile of immune cell activation, autoantigen upregulation, and enhanced E2F pathway transcription. Accordingly, E2fl-deficient mice manifested only mild disability upon induction of experimental autoimmune encephalomyelitis (EAE). Furthermore, PBMCs from Avonex-treated patients had lower expression of E2F targets. The profile was enriched in genes known to harbor MS-associated polymorphisms, or localized to MS susceptibility chromosomal regions. Our study shows that PBMC microarrays reflect MS pathobiology that can be validated in the EAE model. (C) 2004 Elsevier B.V. All rights reserved.
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