Journal
JOURNAL OF IMMUNOTHERAPY
Volume 27, Issue 3, Pages 227-231Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002371-200405000-00007
Keywords
lymphoma; idiotype; T-cell; adoptive
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There is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is the adoptive transfer of in vitro generated T cells. This strategy has been used to treat posttransplantation EBV-related diseases.' The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoina.(2) Investigating the adoptive transfer of specific T cells to idiotype derived peptides in a murine lymphoma model is therefore an important part of the clinical translation of this alternative approach. We have generated an idiotype-specific T cell line, able to recognise a defined, naturally processed idiotype-derived epitope. This line has been used to successfully treat mice with disseminated lymphoma supporting the clinical use of idiotype specific T cells.
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