Journal
ANNALS OF MEDICINE
Volume 36, Issue -, Pages 5-14Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17431380410032553
Keywords
Brugada syndrome; electrophysiology; long-QT syndrome; sudden cardiac death; ventricular arrhythmias
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Funding
- NHLBI NIH HHS [HL47678] Funding Source: Medline
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Regional differences in repolarization characteristics of distinct cell types are responsible for the inscription of the J wave and T wave of the electrocardiogram (ECG). Amplification of these electrical heterogeneities contributes to the development of a variety of cardiac arrhythmias. This brief review examines the ionic and cellular basis for these heterogeneities and their role in the Brugada and long-QT syndromes. Both cases involve an accentuation of transmural dispersion of repolarization (TDR). In the case of the Brugada syndrome, TDR is accentuated as a result of a preferential abbreviation of the right ventricular epicardial action potential, whereas in the long-QT syndrome, accentuation of TDR is secondary to a preferential prolongation of the action potential of the M cell.
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