Journal
AQUATIC TOXICOLOGY
Volume 156, Issue -, Pages 17-20Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquatox.2014.07.007
Keywords
Pyrethroid; 4-hydroxy bifenthrin; ELISA; Menidia beryllina; Endocrine disruption; Environmental estrogen
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Funding
- UNCW Center for the Support of Undergraduate Research and Fellowships (CSURF)
- UNCW Department of Biology and Marine Biology
- California Department of Fish and Wildlife [E1183010]
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Bifenthrin, a pyrethroid pesticide, is estrogenic in vivo in fishes. However, bifenthrin is documented to be anti-estrogenic in vitro, in the ER-CALUX (estrogen receptor) cell line. We investigated whether metabolite formation is the reason for this incongruity. We exposed Menidia beryllina (inland silversides) to 10 ng/l bifenthrin, 10 ng/l 4-hydroxy bifenthrin, and 10 ng/l bifenthrin with 25 mu g/l piperonyl butoxide (PBO) - a P450 inhibitor. Metabolite-exposed juveniles had significantly higher estrogen-mediated protein levels (choriogenin) than bifenthrin/PBO-exposed, while bifenthrin alone was intermediate (not significantly different from either). This suggests that metabolites are the main contributors to bifenthrin's in vivo estrogenicity. (C) 2014 Elsevier B.V. All rights reserved.
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