Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 11, Issue 5, Pages 343-346Publisher
WILEY
DOI: 10.1111/j.1468-1331.2004.00780.x
Keywords
Creutzfeldt-Jakob disease; progressive supranuclear palsy; vertical supranuclear ophthalmoplegia
Categories
Ask authors/readers for more resources
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by an akinetic rigid syndrome with vertical supranuclear ophthalmoplegia, early falls, and levodopa resistance. The pathological substrate of PSP consists of filamentous tau degenerative lesions affecting neurons and glia. Other disorders can present with a similar clinical picture, most commonly corticobasal degeneration and multiple system atrophy. Non-neurodegenerative disorders are rare causes of the PSP syndrome. In this report we describe clinical and pathological features of two cases of Creutzfeldt-Jakob disease (CJD) presenting with the PSP syndrome and discuss which features may help prevent misdiagnosis. To our knowledge, this is the first report of cases of CJD with autopsy confirmation that presented with a PSP syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available