Solvent-free synthesis of 1,5-benzothiazepines and benzodiazepines on inorganic supports

1,5-Benzothiazepines and 1,5-benzodiazepines have been synthesized in solvent-free conditions from chalcones and o-aminothiophenol or o-phenylenediamine in the presence of inorganic support. Silica gel was found to be an effective support for the synthesis of 1,5-benzothiazepines, whereas alumina was effective for the synthesis of 1,5-benzodiazepines.