Journal
LUNG CANCER
Volume 44, Issue 2, Pages 167-174Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.lungcan.2003.11.005
Keywords
basic fibroblast growth factor; non-small cell lung carcinoma; growth inhibitor; antisense oligonucteotides; RT-PCR
Categories
Ask authors/readers for more resources
Basic fibroblast growth factor (bFGF) is closely involved in angiogenesis and tumor growth of various cancers, but its rote in proliferation and differentiation of non-small cell lung cancer (NSCLC) remains to be defined. The majority of NSCLC cell lines produce elevated protein levels of bFGF but do not secrete comparable amounts. We therefore investigated the influence of bFGF on the proliferation of three human NSCLC cell tines. Our experiments demonstrate that intracellular bFGF level and bFGF mRNA expression correlated with the proliferation rate in at[ three cell lines. Delivery of a bFGF neutralizing monoclonal antibody, anti-sense oligonucteotides or a vector expressing bFGF antisense cDNA into the cells inhibited tumor cell growth. Delivery of recombinant bFGF into a bFGF-negative cell line led to increased proliferation. These findings suggest that bFGF stimulates the growth of tumor cells by intracrine mechanisms. Strategies to inhibit bFGF in NSCLC may therefore be a promising approach in NSCLC therapy. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available