Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 4, Issue 5, Pages 593-608Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2004.01.003
Keywords
interferons; cytokines; cytokine receptors; antiviral protection; immune and inflammatory response
Categories
Ask authors/readers for more resources
With the sequencing of the human genome nearing completion, it appears that all members of the class 11 cytokine receptor family (CRF2) have been identified and partially characterized. The entire family is composed of exactly one dozen members. Eleven of them combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines divided into four structurally related groups: 6 cytokines of the IL-10 family, 17 type I IFNs, I type 11 IFN and 3 IFN-lambdas. The last CRF2 member is the soluble receptor which can neutralize the action of one of the cytokines of the IL-10 family, IL-22. Although the extracellular domains of all CRF2 proteins reveal primary and structural homology, their intracellular domains are very dissimilar. Nevertheless, signaling events induced through various combinations of CRF2 subunits partially overlap, leading to the induction of overlapping but cytokine-specific biological activities. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available