Journal
NATURE REVIEWS IMMUNOLOGY
Volume 4, Issue 5, Pages 325-335Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1351
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The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by many effector and memory T cells after initial antigen encounter. This review discusses the role of E-, P- and L-selectin and their glycoprotein ligands in this process. During activation, some T cells differentiate to bind E- selectin through induced expression of fucosyltransferase-VII and to bind P- and L-selectin through additional expression of core 2 glucosaminyltransferase-I. This inducible expression of selectin ligands, together with the regulation of L-selectin expression, has a role in the recruitment of activated T cells to extralymphoid tissues and sites of inflammation.
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