Journal
AQUATIC TOXICOLOGY
Volume 97, Issue 1, Pages 34-41Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2009.11.016
Keywords
Silver; Nanoparticle; Genotoxicity; Medaka
Categories
Funding
- Munson foundation
- Texas State University-San Marcos NOAA [NA05NOS4261162]
- Maine EPSCoR FBRI Research Project
- Maine Center for Toxicology and Environmental Health
- Memorial Sloan Kettering Cancer Center
- NATIONAL CENTER FOR RESEARCH RESOURCES [R24RR024790] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [R24OD011120] Funding Source: NIH RePORTER
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Nanoparticles are being widely investigated for a range of applications due to their unique physical properties. For example, silver nanoparticles are used in commercial products for their antibacterial and antifungal properties. Some of these products are likely to result in silver nanoparticles reaching the aquatic environment. As such, nanoparticles pose a health concern for humans and aquatic species. We used a medaka (Oryzias latipes) cell line to investigate the cytotoxicity and genotoxicity of 30 nm diameter silver nanospheres. Treatments of 0.05, 0.3, 0.5, 3 and 5 mu g/cm(2) induced 80, 45.7, 24.3, 1 and 0.1% survival, respectively, in a colony forming assay. Silver nanoparticles also induced chromosomal aberrations and aneuploidy. Treatments of 0, 0.05, 0.1 and 0.3 mu g/cm(2) induced damage in 8, 10.8, 16 and 15.8% of metaphases and 10.8, 15.6, 24 and 24 total aberrations in 100 metaphases, respectively. These data show that silver nanoparticles are cytotoxic and genotoxic to fish cells. (C) 2009 Elsevier B.V. All rights reserved.
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