Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 109, Issue 5, Pages 698-702Publisher
WILEY
DOI: 10.1002/ijc.20038
Keywords
melanoma; cytolytic T lymphocytes; antigenic peptide; MAGE; cancer immunotherapy
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We have identified 2 antigens recognized by several melanoma-specific cytolytic T lymphocyte clones isolated from a melanoma patient with a clinical history of tumor regression after immunotherapy. Both antigens are presented by HLA-A2 and encoded by gene MAGE-C2, a cancer-germline gene shown previously to be silent in normal somatic tissues and expressed in 40% of melanomas and in other tumor types. One antigen corresponds to peptide ALKDVEERV(336-344), whereas the other corresponds to peptide LLFGLALIEV(191-200). The CTL clones recognizing these 2 peptides also recognized allogeneic tumor cell lines expressing MAGE-C2 and HLA-A2. These 2 new peptides are the first known MAGE-C antigens and represent promising targets for cancer immunotherapy. (C) 2004 Wiley-Liss, Inc.
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