Journal
IMMUNITY
Volume 20, Issue 5, Pages 509-516Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(04)00111-6
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The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.
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