Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 9, Pages 2049-2057Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.02.034
Keywords
oxazolone; immunomodulation; chemotaxis; T-cell proliferation
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Eleven oxazolone derivatives were synthesized and characterized by H-1 NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one (11), 4[(E)-(4-methoxyphenyl)methylidene]-2-methyl-1, 3-oxazol- 5 -one (12) and 4-[(E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) was found to be the most potent immunomodulator in the series. (C) 2004 Elsevier Ltd. All rights reserved.
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