4.4 Article

-1 Frameshifting at a CGA AAG hexanucleotide site is required for transposition of insertion sequence IS1222

Journal

JOURNAL OF BACTERIOLOGY
Volume 186, Issue 10, Pages 3274-3277

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.10.3274-3277.2004

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Funding

  1. NIGMS NIH HHS [R01 GM048152, R01-GM48152] Funding Source: Medline

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The discovery of programmed - 1 frameshifting at the hexanucleotide shift site CGA_AAG, in addition to the classical X_XXY_YYZ heptanucleotide shift sequences, prompted a search for instances among eubacterial insertion sequence elements. IS1222 has a CGA_AAG shift site. A genetic analysis revealed that frameshifting at this site is required for transposition.

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