4.7 Article

Iodinated biaryls synthesized by the direct dehydrodimerization of iodoarenes using phenyliodine(III) bis(trifluoroacetate) (PIFA)

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 346, Issue 6, Pages 675-681

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200404024

Keywords

biaryls; C-C coupling; hypervalent iodine reagents; iodoarenes; synthetic methods

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Multiply iodinated biaryls can be prepared in yields up to 75% by direct oxidative coupling reaction of the iodinated arenes. The PIFA-mediated dehydrodimerization is superior to all other known methods. The developed protocol is reliable and easy to perform.

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