Journal
TOXICON
Volume 43, Issue 6, Pages 737-740Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2004.02.014
Keywords
amino acid sequence; Na+-channel; patch-clamp; scorpion toxins; Tityus cambridgei
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A toxic peptide earlier denominated Tc48b [Toxicon 40 (2002) 557] was purified to homogeneity and its ammo acid sequence determined. It has 64 amino acid residues stabilized by four disulfide bridges with a molecular weight of 7,385.2 atomic mass units (a.m.u.). It affects Na+-permeability ill pituitary GH3 cells ill Culture, in a similar fashion as those reported for alpha-scorpion toxins, contrary to most of the New World scorpion toxins that are beta-toxins. (C) 2004 Elsevier Ltd. All rights reserved.
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