Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 98, Issue 5, Pages 318-321Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.trstmh.2003.09.001
Keywords
malaria; Plasmodium falciparum; Artemisia annua; artemisinin; traditional antimalarials; Congo
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The Chinese medicinal plant Artemisia annua L. (Annual Wormwood) contains the antimatarial compound artemisinin. The locally grown herb may offer an additional toot for the control of malaria, especially in poor countries where modern antimatarial drugs are often unavailable. In an open, randomized, controlled pilot trial, we investigated the efficacy and safety of traditional tea preparations of Artemisia annua in the treatment of uncomplicated malaria. Treatment resulted in a quick resolution of parasitaemia and of clinical symptoms. After 7 d of medication, cure rates were on average 74% for the Artemisia preparations compared with 91% for quinine. However, recrudescence rates were high in the Artemisia groups. Therefore, monotherapy with Artemisia annua L. cannot be recommended as alternative to modern antimalarials, but may deserve further investigation. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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