Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 5, Pages 722-727Publisher
WILEY
DOI: 10.1359/JBMR.040113
Keywords
thalassemia; osteoporosis; hypogonadism; osteoprotegerin; RANKL
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Osteoporosis represents an important cause of morbidity in adult thalassemic patients, and its pathogenesis has not, as yet, been completely clarified. In our study, we observed that thalassemic patients showed a significantly lower OPG/RANKL ratio than normal subjects. These data are extremely important for the possible therapeutic use of RANKL antagonists such as OPG in thalassemia-induced osteoporosis.
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