Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 113, Issue 9, Pages 1271-1276Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200420945
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Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. in mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cyrokine for the induction of hepcidin during inflammation and that the IL-6-hepcidin axis is responsible for the hypoferremia of inflammation.
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