Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 58, Issue 1, Pages 17-21Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2003.08.019
Keywords
selenium; rainbow trout; oxidative stress; superoxide radical; teratogensis; biotransformation
Categories
Ask authors/readers for more resources
Although selenium is required by vertebrates, toxicity call arise at concentrations only slightly greater than those they require. The toxicity of Se is thought to arise from its ability to substitute for sulfur during the assembly of proteins. However, recent Studies also indicate that some forms of selenium are capable of generating oxidative stress in an in vitro test system that includes glutathione. L-Selenomethionine. the predominant form of selenium in the eggs Of Oviparous vertebrates, does not generate oxidative radicals in this system, but lesions consistent with oxidative stress have been identified in fish and birds with high concentrations of Se. Here we report oil the abitity of rainbow trout embryos to transform L-Selenomethionine to a form capable of producing a superoxide radical. Oxidative stress appears to be generated by methioninase enzyme activity in the embryos that liberates methylselenol from L-Selenomethionine. Methylselenol redox cycles in the presence of glutathione producing superoxide and likely accounts for oxidative lesions present ill fish and birds environmentally exposed to excessive loads of selenomethionine. (C) 2003 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available